A new chemical probe for the detection of the cancer-linked galectin-3.
نویسندگان
چکیده
A chemical probe was developed for the detection of the emerging cancer marker galectin-3. The probe contains a benzophenone moiety which covalently attaches itself to the protein upon binding and irradiation. Introduction of a fluorescent label via'click' chemistry allows the labelled proteins to be visualized in a gel. With the probe, selective visualization of galectin-3 in protein mixtures was shown and remarkably even in cell lysates.
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ورودعنوان ژورنال:
- Organic & biomolecular chemistry
دوره 4 23 شماره
صفحات -
تاریخ انتشار 2006